Effects of DHMEQ, a Novel Nuclear Factor-.KAPPA.B Inhibitor, on Beta Cell Dysfunction in INS-1 Cells
نویسندگان
چکیده
منابع مشابه
Effects of DHMEQ, a novel nuclear factor-kappab inhibitor, on beta cell dysfunction in INS-1 cells.
AIMS Recent studies suggest that nuclear factor-kappaB (NF-kappaB) activation has an important role in leading to beta cell dysfunction in both type 1 and type 2 diabetes. In this study we tested this hypothesis by investigating the effects of dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, on tumor necrosis factor-alpha (TNF-alpha)-induced beta cell dysfunction. METHODS ...
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PURPOSE The objective of the study was to determine the effects of a novel selective nuclear factor kappaB (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), in thyroid carcinoma cells in vitro and in vivo and to additionally elucidate the molecular mechanisms underlying the action of this chemotherapeutic agent. EXPERIMENTAL DESIGN In the in vitro experiments, the induction of ap...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2008
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.k07e-036